closes #216 (2)

BjornFJohansson · May 8, 2024 · d1b52d5 · d1b52d5
1 parent 62de1dd
commit d1b52d5
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diff --git a/src/pydna/crispr.py b/src/pydna/crispr.py
@@ -29,7 +29,8 @@ class _cas(ABC):
     def __init__(self, protospacer):
         self.protospacer = protospacer.upper()
         self.compsite = re.compile(
-            f"(?=(?P<watson>{protospacer}{self.pam}))|(?=(?P<crick>{rc(self.pam)}{rc(protospacer)}))", re.UNICODE
+            f"(?=(?P<watson>{self.protospacer}{self.pam}))|(?=(?P<crick>{rc(self.pam)}{rc(self.protospacer)}))",
+            re.UNICODE,
         )
 
     @abstractmethod

diff --git a/tests/test_module_crispr.py b/tests/test_module_crispr.py
@@ -42,6 +42,8 @@ def test_crispr():
             a.rc(),
         ]
 
+    assert target.cut(cas9("GTTACTTTACCCGACGTCCC")) == target.cut(cas9("GTTACTTTACCCGACGTCCC".lower()))
+
 
 if __name__ == "__main__":
     pytest.main([__file__, "-vv", "-s"])